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Clint Mitchell Selected Research

CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)

8/2009Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
9/2008Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
9/2008Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

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Clint Mitchell Research Topics

Disease

18Neoplasms (Cancer)
03/2011 - 07/2003
10Carcinoma (Carcinomatosis)
01/2016 - 02/2005
5Breast Neoplasms (Breast Cancer)
11/2010 - 11/2005
5Mitochondrial Diseases (Mitochondrial Disease)
11/2010 - 02/2005
4Glioblastoma (Glioblastoma Multiforme)
02/2010 - 07/2003
4Glioma (Gliomas)
02/2010 - 08/2003
3Prostatic Neoplasms (Prostate Cancer)
01/2016 - 04/2008
3Infections
03/2011 - 07/2003
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2010 - 09/2008
2Renal Cell Carcinoma (Grawitz Tumor)
03/2011 - 07/2003
2Melanoma (Melanoma, Malignant)
02/2010 - 08/2003
2Colonic Neoplasms (Colon Cancer)
08/2009 - 09/2007
2Necrosis
08/2003 - 07/2003
1Kidney Neoplasms (Kidney Cancer)
03/2011
1Ataxia Telangiectasia (Louis Bar Syndrome)
11/2010
1Reperfusion Injury
10/2010
1Left Ventricular Dysfunction
10/2010
1Infarction (Infarctions)
10/2010
1Myocardial Infarction
10/2010
1Brain Neoplasms (Brain Tumor)
09/2009
1Drug-Related Side Effects and Adverse Reactions
08/2009
1Carcinogenesis
01/2009
1Hepatocellular Carcinoma (Hepatoma)
09/2008
1Adenocarcinoma
09/2008

Drug/Important Bio-Agent (IBA)

6VorinostatFDA Link
08/2010 - 12/2007
5Proteins (Proteins, Gene)FDA Link
01/2016 - 03/2005
5CeramidesIBA
03/2011 - 08/2009
5Sorafenib (BAY 43-9006)FDA Link
08/2010 - 09/2008
42- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluorobenzamideIBA
08/2011 - 11/2005
4Reactive Oxygen Species (Oxygen Radicals)IBA
10/2010 - 09/2008
4Phosphotransferases (Kinase)IBA
05/2010 - 02/2005
4Pharmaceutical PreparationsIBA
05/2010 - 11/2005
3AZD 6244IBA
08/2011 - 03/2008
3tanespimycin (17AAG)IBA
03/2011 - 09/2008
3Caspase 3 (Caspase-3)IBA
10/2010 - 11/2005
3Drug CombinationsIBA
08/2010 - 11/2005
3CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
08/2009 - 09/2008
3Histone Deacetylase InhibitorsIBA
08/2009 - 12/2007
37-hydroxystaurosporine (UCN 01)IBA
03/2008 - 02/2005
2Sildenafil Citrate (Viagra)FDA Link
01/2016 - 10/2010
2Doxorubicin (Adriamycin)FDA LinkGeneric
01/2016 - 10/2010
2Death Domain ReceptorsIBA
01/2016 - 05/2010
2Caspase 8 (Caspase-8)IBA
03/2011 - 02/2005
2alvocidib (flavopiridol)IBA
11/2010 - 12/2007
2Lapatinib (GW572016)FDA Link
11/2010 - 11/2009
2obatoclaxIBA
11/2010 - 11/2009
2Caspase 9IBA
10/2010 - 04/2008
2geldanamycinIBA
05/2010 - 09/2008
2Mitogen-Activated Protein KinasesIBA
05/2010 - 09/2008
2Beclin-1IBA
08/2009 - 07/2009
2Mitogen-Activated Protein Kinase 3IBA
09/2008 - 02/2005
2Peptide Hydrolases (Proteases)FDA Link
09/2008 - 12/2007
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2008 - 02/2005
2ras ProteinsIBA
03/2005 - 02/2005
2DNA (Deoxyribonucleic Acid)IBA
08/2003 - 07/2003
1Caspase 1 (ICE Protease)IBA
01/2016
1FenretinideIBA
03/2011
1Aligeron (AS 2)IBA
03/2011
1AD 5IBA
03/2011
1RoscovitineIBA
11/2010
1Histones (Histone)IBA
11/2010
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
11/2010
1Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
10/2010
1Oxygen (Dioxygen)IBA
08/2010
1Heat-Shock Proteins (Heat-Shock Protein)IBA
05/2010
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
05/2010
1Endoplasmic Reticulum Chaperone BiPIBA
05/2010
1dihydroceramide desaturaseIBA
02/2010
1ThioredoxinsIBA
02/2010
1CytokinesIBA
02/2010
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
09/2009
1SphingolipidsIBA
09/2009
1sphingosine kinaseIBA
09/2009
1IsoenzymesIBA
09/2009
1Valproic Acid (Depakote)FDA LinkGeneric
08/2009
1Protein CIBA
08/2009
1Autophagy-Related ProteinsIBA
07/2009
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
07/2009
1bafilomycin A1IBA
07/2009
13-methyladenineIBA
07/2009
1Small Interfering RNA (siRNA)IBA
07/2009
1NeurosteroidsIBA
07/2009
1PX-866IBA
01/2009
1ral Guanine Nucleotide Exchange FactorIBA
01/2009
1p38 Mitogen-Activated Protein KinasesIBA
09/2008
1MAP Kinase Kinase 1IBA
09/2008
1Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
04/2008
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
04/2008
1Lovastatin (Mevacor)FDA LinkGeneric
04/2008
1TransferasesIBA
03/2008
1CathepsinsIBA
12/2007
1Cyclin-Dependent Kinases (cdk Proteins)IBA
12/2007
1Inositol (Myoinositol)IBA
09/2007
1PlatinumIBA
09/2007
1ErbB Receptors (EGF Receptor)IBA
09/2007
1BBR3610IBA
09/2007
1Phosphatidylinositols (Phosphatidylinositol)IBA
08/2006

Therapy/Procedure

3Therapeutics
08/2010 - 07/2003
2Drug Therapy (Chemotherapy)
08/2003 - 07/2003
2Radiotherapy
08/2003 - 07/2003